Denise Johnson Miller
Memorial Sloan Kettering Cancer Center, USA
Title: Update on genetics of breast and gynecologic cancers
Biography
Biography: Denise Johnson Miller
Abstract
The keynote address will provide evidence based information to guide clinicians in evaluation and treatment of high risk for genetic breast and gynecologic cancers. A review of BRCA gene function, incidence of genetic mutations related to BRCA and other high risk genes will be provided. The use of next gene sequencing and multi-gene panels and discussion of new genes that are high, moderate and low penetrance pathologic mutations that impact risk of developing breast/gynecologic cancers will be noted. Clinical management of carriers, of pathogenic gene variants will be reviewed with incidence of primary and secondary cancers. Impact of high risk for breast/gynecologic cancers pathologic genetic mutations on patient’s wellbeing, economics of surveillance vs. prophylactic surgery or chemo prevention will be addressed.
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